Identify DNA profiles of multiple cancers with one core panel
Efficiently detect single nucleotide variants, insertions and deletions, copy number variations, and microsatellite instability with targeted NGS of 60 genes relevant for colorectal, breast, melanoma, pancreatic, NSCLC, and other cancer research.
Detect confidently with Archer VARIANTPlex NGS Panels for DNA.
Learn how the VARIANTPlex Core Solid Tumor panel can identify key genomic alterations for your research.
Request a consultationSpecifications | |
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Targeted genes | 60 |
Genomic alterations | SNVs, indels, CNVs, ITDs, MSI |
Input nucleic acid required* | ≥10 ng |
Recommended number of reads | 4.5 M |
Hands-on time | <3.5 hours |
Total library prep time | 1.5 days |
Platform compatibility | Illumina® |
Reagent format | Lyophilized or liquid |
Supported sample types | FFPE, fresh frozen, cytology smear, FNA |
*Input mass requirements vary depending on type and quality. Unless the tumor cellularity and sample quality are high, 50 ng of FFPE-derived nucleic acid should be considered the minimum recommendation. If input is not limiting, 200 ng is recommended.
Customize this NGS panel by adding any of our functionally-tested designs or create a new panel that fits your exact requirements with Assay Marketplace.
Talk with our technical sales team. Learn how the VARIANTPlex Core Solid Tumor panel can identify key genomic alterations for your research.
Request a consultationYes, DNA and RNA from a single sample can be analyzed with VARIANTPlex™ and FUSIONPlex™ panels to provide a genomic profile of the cancer.
For comprehensive genomic profiling, pair the VARIANTPlex Complete Solid Tumor v2 and FUSIONPlex Pan Solid Tumor v2 panels to interrogate 511 genes for SNVs, indels, CNVs, fusions, exon-skipping, and splicing variants, as well as assessment of HRD, MSI, and TMB. Additionally, the IMMUNOVerse™ TCR panel can provide tumor-infiltrating lymphocyte information relevant for solid tumor characterization. All Archer panels have parallel workflows, allowing for streamlined comprehensive solid tumor profiling.
Most VARIANTPlex assays can be used for both somatic and germline variant detection. However, some custom‑designed panels for germline applications may not be suitable with FFPE tissue with shorter fragment lengths.
As opposed to traditional priming methods, AMP chemistry enables tiling primers across both strands of DNA, optimally covering targeted regions for amplification and characterization of challenging, yet relevant alterations such as internal tandem duplications. Additionally, AMP chemistry uses molecular barcode adapters that bind to DNA fragments before amplification, allowing for efficient amplification of targets even from degraded or fragmented nucleic acid input, such as DNA from FFPE tissue and ctDNA from plasma.
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