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Mutation detection

Convenient mismatch endonuclease assays that are based on analysis of PCR products spanning your region of interest

  • Cost effective—only standard molecular biology equipment required
  • Save time—easy to use and compatible with high throughput processes
  • Detect a wide range of mutations—get the information you need

Alt-R® Genome Editing Detection Kit »

For estimating on-target editing efficiency or assessing known off-target effects in your CRISPR experiments, we recommend using the Alt-R Genome Editing Detection Kit (also compatible with ZNF- and TALEN-driven genome editing systems). This T7 endonuclease I mismatch cleavage assay is ideal for directly analyzing your reaction products to detect multiple-base insertions and deletions.

Surveyor® Mutation Detection Kit »

The Surveyor Mutation Detection Kit allows simple, robust detection of SNPs. The key component, Surveyor Nuclease, cleaves mismatched DNA caused by single-nucleotide polymorphisms and small insertions or deletions.